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Retrospective review of seven patients with obesity simultaneously treated with a combination of a glucagon-like peptide-1 receptor agonist and a meal replacement product

However, semaglutide is a complex peptide requiring stringent cold-chain storage (28C) and sophisticated manufacturing

Findings: Change in body weight : The mean percent change in body weight was -20.2% with tirzepatide (95% CI, -21.4 to -19.1) and -13.7% with semaglutide (95% CI, -14.9 to -12.6)

Manageable with minimal lifestyle disruption

IGF-1 LR3, however, can be administered exogenously to bypass this indirect process and produce faster results