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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
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After washing with BSA/PBS, cells were fixed with Cytofix/Cytoperm (BD Biosciences) for 10 minutes and permeabilized with Perm/Wash solution
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In both astrocytes and glioblastoma/astrocytoma cells, the majority of cysteine originates from reduction of cystine imported by the x c cystine-glutamate exchanger
Front Immunol (2021) 12:696061
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