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However, the combined administration of CCl 4 with MTX caused an intense inflammatory cell infiltration, steatosis and degradation of hepatocytes, dysplastic hepatocytes, nodules with intense congestion of central and portal veins, focal necrosis, prominent hepatic tissue cirrhotic changes, and diffused Kupffer cell proliferation (Figure 4F)

Read counts were normalized by the trimmed mean of M -values method and differential expression was calculated using R package edgeR (v.3.28.1) and genewise negative binomial generalized linear models with quasi-likelihood tests method was used for statistical tests

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Luckily, Golds urologist recommended a different treatment option: prostate artery embolization