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In agreement with in vitro findings, DMF treatment induced the expression of Cbs, Ahcy, and NRF2 targets such as Gclc, Gclm, and Slc7a11, but not that of Cse (Fig
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Hence, the bioavailability of all other formulations and routes of administration can be compared to this reference value as an absolute standard, and from this the equation for absolute bioavailability can be derived: The absolute bioavailability then is the dose-corrected area under the curve (AUC) non-intravenous divided by AUC intravenous
Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA
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