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Leehey DJ et al
168 Over the past few decades, inhibitors targeting key transporters such as P-gp, MRPs, and BCRP have evolved through three major generations
Dose: 2 mg (2000 mcg) daily after Week 1 titration
In some cases, it may worsen diabetic retinopathy
These agents mimic the biological action of the native incretin hormone GLP-1 but are structurally modified to resist degradation by the enzyme dipeptidyl peptidase 4 (DPP-4), thereby extending their half-life and duration of action (Zheng et al., 2024
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