glutathione is used as a cofactor by (1) multiple peroxidase enzymes, to detoxify peroxides generated from oxygen radical attack on biological molecules
The amount of oral intake needed to achieve gastric and intestinal fullness and signal satiety to the brain through the gut-brain axis can overwhelm the evolutionarily determined metabolic capacity of peripheral organs such as liver, pancreas, fat tissue, and muscles
These medications also improve fasting glucose, cholesterol levels, and insulin sensitivity - critical factors for women with PCOS, as approximately 70% are insulin resistant and 80% are overweight or obese
Furthermore, another secondary analysis of the STEP-HFpEF and STEP-HFpEF DM trials showed that semaglutide reduced C-reactive protein levels and improved symptoms, physical limitations, and exercise function in HFpEF obese patients [84]
It is being developed for the treatment of obesity and type 2 diabetes, and is currently in phase II clinical stage