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Because of a lack of evidence, the Renal Illness Improving Global Outcomes (KDIGO) clinical practice guidelines for anaemia in chronic renal disease do not advocate LC as an adjuvant treatment (KDIGO, 2012)
For instance, a number of ongoing or completed trials are evaluating inhibitors of the PI3K-AKT-mTOR cascade, such as gedatolisib (NCT03065062) in advanced solid tumors, capivasertib (NCT04305496) in hormone receptor-positive breast cancer, and alpelisib (NCT02437318), which has shown efficacy in advanced breast cancer and is already approved for PIK3CA-mutated cases
Common UK options include Evorel or Estradot patches and Oestrogel
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However, they do not fix the underlying problem
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