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Photodecaging of a Mitochondria-localized iridium(III) endoperoxide complex for two-photon photoactivated therapy under hypoxia
this treatment improves immune regulation and limits gland damage (Geetha et al 2023, Phagoora et al
The question is whether topical delivery is enough
Hydrosoluble molecules with free radical scavenging properties such as ascorbic acid, albumin, bilirubin, urates and thiols, liposoluble coenzyme Q10, and vitamin E interfere with the lipid peroxidation by neutralizing the free radicals
632 Di-Huang-Yin-Zi effectively decreases ROS and MDA levels in prefrontal cortex, increases the expression of ferroptosis-related markers GPX4 and SLC7A11 and, and decreases iron deposition, thereby improving depressive symptoms and synaptic ultrastructure of cortical regions in post-stroke depressed (PSD) rats, suggesting that Di-Huang-Yin-Zi can reduce the symptoms and enhance function in PSD rats by inhibiting ferroptosis through SLC7A11/GPX4 pathway
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