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Among over 500 obese patients with OSAS, long-term tirzepatide treatment led to significant reductions in body weight, AHI, and oxygen desaturation index, with particularly pronounced benefits in patients with concurrent glucose and lipid metabolism abnormalities (52)

Higher total daily choline intakes were linked to a higher risk of cardiometabolic mortality (i.e., death attributed to cardiovascular disease or type 2 diabetes mellitus) in large prospective cohorts of three ethnic groups: blacks (n=49,858), whites (n=23,766), and Chinese (n=134,001) (44)

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The closest thing to a consensus datapoint remains Novos own guidance that the combined pricing impact will be low single digit negative for 2026 growth