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Orlistat remains the only oral weight-loss medication currently NHS-licensed for obesity, but it works differently and produces around 3% weight loss, compared to the 11% to 14% reported for the GLP-1 pills
It has not received FDA approval, and available data derives from early-phase trials rather than the large-scale, long-term studies that underpin semaglutides established clinical standing
Food and Drug Administration: Compounding and the FDA: Questions and Answers Thinking of Using a Compounding Pharmacy
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