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Thyroid considerations apply to Retatrutide as they do to all GLP-1 class medications

National Academies of Sciences, Engineering, and Medicine

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Expert Opin Ther Pat (2020) 30:78194

The article says combination therapy is typically considered when glycemic control is inadequate on GLP-1 monotherapy, or when cost, adherence or side effects favor adding an oral DPP-4 instead of increasing the GLP-1 amount