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That matters because tolerability tracks the size of the swing during starts, dose jumps, missed doses and restarts, while at stable maintenance it tracks average concentration which splitting leaves unchanged by design

Who suffers most from B12 deficiency

Folate deficiency may result in moderately low total serum vitamin B12 concentrations because both folate as a cosubstrate (methyl donor) and vitamin B12 (as a coenzyme) are required in the remethylation metabolic pathway of homocysteine (see Figure 22b.2) (Klee, 2000)

This is exemplified by the FUT2 gene, which influences the composition of the gut microbiome

How can I reduce the level of vitamin B12