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5-LOX as a crucial enzyme in the arachidonic acid cascade can mediate 5-OH-eicosatetraenoic acid (5-HETE) and leucotrienes production with the assistance of 5-LO activating protein (FLAP)

In a mouse study, selenium supplementation increased the expression of certain glutathione enzymes as well as increasing their activity

This paradox suggests DSIP acts as a biochemical trigger: it initiates a cascade of neuroendocrine changes that persist long after the molecule itself is cleared

If bleeding results from an ulcer, infection, or inflammation, the doctor may prescribe medications

However, it's also found in foods, most commonly animal products like red meat, poultry and fish