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What are the TRIUMPH trials
27 Various molecules involved in T cell activation, including CTLA4, CD40, CD28, IL-21, and ILRA/IL2, have been found to be elevated in RA
Alterations in proteasome composition and reduced expression of subunits such as PSMA7 and PSMB5 impair proteolytic efficiency, leading to accumulation of damaged proteins [101]
However, this changes when a drug is listed on the FDA shortage list
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