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The cleaved N-terminal fragment of GSDME forms pores in the cell membrane, triggering pyroptosis, which is characterized by cell swelling, rupture, and the release of pro-inflammatory signals
Additionally, they impact the occurrence and severity of nearly all chronic and degenerative diseases, encompassing cancer, atherosclerosis, stroke, arthritis, diabetes, osteoporosis, neurodegenerative conditions, inflammatory diseases, and skin disorders (Gaboon, 2011)
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Bouhoute M, et al
Mitochondrial dysfunction in Parkinson's disease
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