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The H 2 S-related RSS per-sulphides and poly-sulphides can be generated by the same enzymatic systems that are involved in H 2 S metabolism, and play a possibly as-yet-underestimated role in signalling in human health and disease, 102,103,104 which is also briefly discussed below

BPC-157 in Inflammatory Bowel Disease (IBD) In ulcerative colitis and Crohns disease models, BPC-157 has: Reduced mucosal damage and bleeding Lowered inflammation markers Promoted rapid tissue healing Minimized recurrence of flare-ups 4

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Preclinical and phase I clinical trial data for a triple GLP1GIPglucagon receptor co-agonist therapy (LY3437943) suggest that it is effective at inducing weight loss, without inducing adverse effects that would require discontinuation