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As it could not been synthesized by human body, the primary intake of which is from dietary sources such as ripe tomatoes, pink guavas and several other red fruits and vegetables ( In vitro , the configuration transformation from trans-isomer to cis-isomer can be accomplished through light, heat and specific chemical processes

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The upregulation of CCN2, FN1, COL1A1, COL3A1, and HMOX1, and the downregulation of GPX4 were also restrained after ML364 treatment in the kidney of UUO mice (Fig