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Denny et al., 2012)

Now heres the funny bit The MHRA in responding to our petition stated: Vitamin B12 could not legally be classified as a medicine that can be made available for sale without prescription in pharmacies because it is an injection and because the condition it is licensed to treat, pernicious anaemia, needs a clinician to diagnose it, and monitor its treatment (see point IV above)

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Phosphodiesterase Inhibition : Caffeine inhibits phosphodiesterase enzymes, leading to increased levels of cyclic adenosine monophosphate (cAMP), which amplifies cellular energy signaling and enhances cognitive performance

In Phase 2 clinical trials, the safety profile was broadly consistent with other incretin-based therapies, with gastrointestinal side effects being the most commonly reported