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Advances in cardiac-specific delivery vectors and high-fidelity Cas9 variants are expected to accelerate the clinical translation of this approach
However, self-directed microdosing or use of compounded versions introduces additional risks
Quality of unregulated supply is also a real, separate risk
Gaglia JL et al
The study found that peripheral endothelial dysfunction independently correlated with future cardiovascular events, thus providing additional clinical significance for risk stratification in HFpEF patients
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