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The nuclear localization signal (NLS) (residues 617633) is localized at the junction between the DBD and the hinge region (residues 624665) and is responsible for nuclear import of the receptor 50,51
Bupropion-naltrexone users had an incidence of 15 per 1,000 person-years
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This was accompanied by the induction of both white and brown adipocyte markers, alongside the downregulation of anti-adipogenic genes like delta-like 1 homolog ( DLK1 ), forkhead box protein O1 (FOXO1), and Wnt family member 3 A ( WNT3A ) in hMSC [16]
