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The rate shows a clear dose-response pattern: in the SURMOUNT-1 trial published in the New England Journal of Medicine (N=2,539 adults followed for 72 weeks), reported rates climbed from roughly 12% at the 2.5 mg starting dose to 23% at the 15 mg top dose, compared to about 8% on placebo

Glucagon receptor activation has been associated with modest increases in calcium absorption and bone formation markers in preliminary studies, though this data is not yet definitive enough to call it a proven benefit

These medications can interact with other medicines you're taking, particularly other diabetes medications, blood pressure medications, and certain psychiatric medications

Triple Agonist A medication targeting three different receptors simultaneously