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The answer is bioavailability
But subjects eventually reached tolerance and a diminished effect
Oxidative stress is tied not only to poor sleep but also to chronic conditions such as heart disease, neurological problems, and inflammation
A kinetic study of drug elimination: the excretion of paracetamol and its metabolites in man
Low incidences of seizures have been reported with oral doses in individuals with or without pre-existing seizure disorders.
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