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It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients
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10.1016/j.molmet.2020.101076 Mol Metab
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Common side effects of GLP-1R activation within the gastrointestinal tract also include nausea, vomiting, constipation, and diarrhea, due to the receptors role in modulating gastric emptying
