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Date: July 25, 2026 Source: NIH/Office of the Director Summary: Newer oral drugs related to semaglutide medications such as Ozempic reduced pleasure-driven eating in mice by quieting a deep brain reward circuit
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STEP-1 (NEJM 2021) established the weight-loss efficacy of semaglutide 2.4mg: 1,961 adults with obesity, mean 14.9% weight loss at 68 weeks versus 2.4% on placebo
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