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Supplementary material The Supplementary material for this article can be found online at: References 1
Abbas HA, Ayoub E, Sun H, Kanagal-Shamanna R, Short N, Issa GC, Yilmaz M, Pierce SA, Rivera D, Cham B, Wing S, Li Z, Hammond D, Jabbour E, Borthakur G, Garcia-Manero G, Andreeff M , Daver N, Kadia TM, Konopleva M, DiNardo CD, and Ravandi F
Depending on clinical appropriateness, the plan may include compounded B12/MIC, NAD+, or Sermorelin, fulfilled through one of the brand's named compounding pharmacies
Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]
Presented for research literature review only York JL et al
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