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Both have similar biological effects that are caused by binding to the IGF-1 receptor (IGF-1R), whereas the IGF-2R is specific for IGF-2 and thought to have no physiological role except serving to degrade IGF-2 28 (Figure 1)
In preclinical and in-vitro studies, FOXO4-DRI has been investigated for its role in senolysis, the selective elimination of senescent ("zombie") cells
Minutes-long half-lives, once-daily studied dosing, and banned in sport
This indicates that the ability to handle stress deteriorates with age, increasing susceptibility to damage
The problem intensifies because compounding pharmacies do not use a single standard concentration
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