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Autons team writes that such discrepancies may stem from differences in disease context, smaller sample sizes, limited statistical power, and variations in drug type, cohorts, and analytical methods

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The NHS pathway under NICE TA1026 currently restricts tirzepatide to a BMI of 40 or above with four of five qualifying conditions, with the threshold widening over the next 12 years

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Stopping treatment is a valid choice but it should be an informed one, made with a clear plan in place, not an impulsive decision made in response to a tough week." Aaliyah Mallard, PharmD For more on what sustainable long-term success looks like on GLP-1 treatment, read our guide on maintaining weight loss long-term, or learn about breaking through weight loss plateaus if you're considering stopping because results have stalled