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This article reviews the distinct miRNAs that orchestrate PD pathogenesis by disrupting mitochondrial homeostasis, lysosomal clearance pathways, ferroptosis regulation, and neuroinflammatory responses
16 Ludvik, B., et al., Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial
In research administration of 500 mg/kg of Tarralin in a KK-A (gamma mice) resulted in reduced glucose levels and enhanced the binding affinity of Glucagon-like peptide (GLP-1) to its receptor in vitro
We demonstrated therapeutic protection of photoreceptor structure and function in a chemically-induced rat model of RP (48% increase in photopic b-wave amplitude), as well as some limited protection in an aggressive genetic mouse model ( rd10 ) of retinal degeneration (~ 31% increase in photopic b-wave amplitude) with once daily application
10.1038/ajg.2014.330 28
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