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Notably, large meta-analyses and collaborative trial datasets have demonstrated no excess risk of severe hypoglycemia, major adverse events, or treatment discontinuation with combination therapy compared with either class alone [11, 28,29,30], supporting the safety and tolerability of combined use in diverse populations
Antioxidant measurement After measuring the total protein concentration in the supernatant from item 2.16 using the BCA protein quantification kit, the expression levels of hydroxylphosphatidylcholine (HYP), myeloperoxidase (MPO), malondialdehyde (MDA), nitric oxide (NO), and reactive oxygen species (ROS) in the colon tissue homogenate were determined according to the operational procedures outlined in the kit manual
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Another thiol-antioxidant, NAC (a precursor of GSH) has also shown great potential to disrupt multispecies endodontic biofilms, suggesting its potential use in root canal and dental plaque treatment (Suk Choi et al., 2017)
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