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Intermittent claudication in peripheral arterial disease In peripheral arterial disease, atherosclerosis of the arteries that supply the lower extremities may diminish blood flow to the point that the metabolic needs of exercising muscles are not sufficiently met, thereby leading to ischemic leg or hip pain known as claudication (see the page on Intermittent Claudication in Peripheral Arterial Disease) (63)

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TB-500 provides complementary anti-inflammatory activity through multiple mechanisms including direct inhibition of NF-B signaling, modulation of immune cell phenotypes, and promotion of inflammatory resolution