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In consideration of the semaglutide-related GI AEs, treatment with GLP-1 RAs should begin with a structured dose-escalation schedule aimed at minimising these effects [64,65,66]

If injection site reactions persist despite proper rotation, consultation with a healthcare provider is warranted to assess technique and consider alternative management strategies

Months 4-12: As you reach higher doses, the medications effects become more pronounced

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Report any suspected side effects to the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or via the Yellow Card app), which helps monitor medication safety