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Consequently , applications include: Bone Research: Osteoblast differentiation, mineralization markers, osteocalcin expression, alkaline phosphatase activity, collagen type I synthesis, and bone density assessment Tendon and Ligament Studies: Fibroblast proliferation, collagen synthesis (types I, III), biomechanical properties, and healing process characterization Cartilage Investigation: Chondrocyte function, proteoglycan synthesis, aggrecan expression, collagen type II, and extracellular matrix maintenance Furthermore , a 2026 PMC review highlights therapeutic peptides, including GH secretagogues, as emerging adjuncts in orthopedic injury management
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The results of our review were synthesized and presented in a narrative fashion in relevant sections discussing the following: GLP-1 receptor agonists: Mechanism of action, glycemic and metabolic control, cardiovascular impact, adverse events (ADEs), GLP-1 agonists and perioperative considerations, and future implications in neurosurgery: Reward pathway, neuroprotective and rehabilitative effects, and other neurosurgical considerations
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