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Research consistently shows that starting at the lowest dose (0.25 mg) and increasing only every four weeks exactly as prescribed minimizes GI disruption

For someone starting at 220 pounds, that difference represents approximately 7 additional pounds of weight loss with Retatrutide compared to Mounjaro

Additionally, GLP-1 analogs reduced energy expenditure, with only tirzepatide showing a significant decrease in the respiratory quotient (RQ) in MC4R KO mice

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This gas produces the characteristic rotten-egg smell of sulfur burps