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The investigators interpreted the findings as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in the Kraus 2014 genetic-validation study
Even tried fecal microbial transplant, which was preceded by a barrage of numerous oral antibiotics of virtually every class, followed by a night long laxative gut-prep as is done prior to a colonoscopy, then introducing the inoculant (donor feces) with a very long tube, to get it well up into the colon, once a day for a week
Losing weight reduces this load, alleviating pain associated with conditions like osteoarthritis
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