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The advanced oxidation protein products (AOPP), elevated in the plasma of patients with DKD, have been found to bind to the CD36 receptor, which can activate the Wnt/catenin signaling pathway as a result of lipid accumulation [48]
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Factors influencing APAP-related hepatotoxicity The most essential determining factor in both the development and severity of APAP hepatotoxicity is the drugs ingested dose, but some argue that the length of time from APAP ingestion to N -acetylcysteine (NAC) therapy (time to NAC) is equally if not more important
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