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In addition to its benefits on glutathione production, coffee enemas also help: With constipation A common problem among those with Hashimotos, hypothyroidism, or low thyroid function

10.1016/s0305-4179(03)00004-4 122 SikiricP.SeiwerthS.RucmanR.DrmicD.StupnisekM.KokotA.et al (2017)

The peptides may have potential roles as adjunctive therapies or alternative treatments for patients who cannot tolerate or do not respond adequately to conventional treatments, but this should be based on careful risk-benefit analysis and appropriate patient selection

But they are not the same compound, and they do not work through the same biological pathway

If your client does not feel the effects after 2 3 injections, then it is more than likely that they are not B12 deficient