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These figures come from how the fixed-ratio blend reconstitutes, not from any approved human dosing of the combination [3] [4]
10.1038/nn.4476 140 FunkK
Loss of MPC function leads to cytosolic pyruvate accumulation and impairs entry into the tricarboxylic acid (TCA) cycle, thereby shifting cells toward a glycolytic phenotype and promoting resistance to OXPHOS inhibition [18]
For some people, the answer is yes, though it is usually temporary and often related to the specific form of the supplement
PMID 947404
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