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Interpretation of the cardiovascular actions of native GLP-1 requires consideration that carboxy- terminal fragments, such as GLP-1(936) and GLP-1(2836), the latter generated from neutral endopeptidase-mediated proteolytic cleavage, retain biological activity in the cardiovascular system through mechanisms independent of the canonical GLP-1R
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The mass spectrometry data on the COA should also clarify this
Were not asking Big Pharma to promote it - they wont, because theres no profit in it
Some influence appetite, while others affect metabolic activity or hormone signaling that impacts body composition
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