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In lab studies by Raun et al
Ferroptosis inhibition attenuates the TGF--induced profibrotic reaction through TGF-/Smad signaling in vitro In addition to inducing ferroptosis activation, TGF- also promotes fibrotic changes in HK-2 cells [25]
The authors concluded that the senescent microenvironment maintained by SASP and p53-pS15 signalling promotes keloid aggressiveness and relapse, and that FOXO4-DRI targets this mechanism selectively
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