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Hoffman DJ, Powell TL, Barrett ES, Hardy DB
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The combined GLP-1/GIP signal in tirzepatide is the mechanistic basis for its ~22.5% SURMOUNT-1 result, outperforming semaglutide's STEP 1 figure by roughly 7.6 percentage points
Also, higher-protein diets have been shown to help conserve muscle mass during periods of energy restriction
Moreover, our findings are only applicable with tirzepatide therapy
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