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Common side effects include mild pain at the injection site, dizziness, or nausea

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Areas of concern include: Hepatic metabolism burden Renal clearance load Altered methylation balance Routine liver and kidney function monitoring would be prudent in long-term experimental use, though controlled safety data remains unavailable

This clinical observation is possibly because the methylcobalamin delivered by this method is better absorbed into the bloodstream, or it is more bio-available, or the effect is more noticeable because of the constantly higher blood level