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Most available data consists of observational reports from weight loss clinics where multiple interventions (caloric restriction, exercise programs, behavioral counseling) are implemented simultaneously, making it impossible to isolate the contribution of lipotropic injections

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A 2019 study found that vitamin B12 supplementation can be associated with an increased risk of colon cancer in older adults when taken at high doses

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The high-dose long-term safety case carries materially more uncertainty than tirzepatide or semaglutide do at comparable durations