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doi:10.1001/jamainternmed.2025.1794
Common Side Effects The University of California, Los Angeles (UCLA) Health website lists these commonly reported side effects: Dizziness Fatigue Gastrointestinal issues, such as diarrhea, constipation and gassiness Headache Stomach pain, nausea, vomiting, pain or bloating These symptoms are usually mild and decrease over time as the body adjusts to the medication
Do not brush your teeth immediately before or after medication use
What makes GLP-1 fatigue different from ordinary dieting fatigue: the deficit is drug-enforced, persistent, and often more aggressive than a voluntary diet
Its potential as a medicine was discovered in 1992 when researchers isolated exendin-4, a longer-lasting simulation of human GLP-1 produced in the saliva of the Gila monster
