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revealed that in liver cancer, hypoxia activates MAT2A expression through hypoxia-inducible factor-1, resulting in increased MAT II enzyme activity and reduced SAM production, which then induces genomic DNA demethylation
The individual amino acids are absorbed and can be used to resynthesize glutathione intracellularly, but this is a slow, rate-limited process that does not produce the acute plasma elevation seen with parenteral routes
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