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For senescence of VSMCs, GLP-1RAs activate Nrf2 and inhibit Rac1 through cAMP/PKA pathways to prevent Ag II-induced senescence [122, 123]

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LC (01723120008, Northeast Pharmaceutical Group Co., Ltd., China) was administered by gavage at 200 mg/kg on day 8 for 2 weeks in the LC group, following modeling, while the Control and EAM groups received an equal volume of saline on day 8