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The pattern is consistent: strong mechanistic plausibility from preclinical data and adjacent human safety, no direct human efficacy or long-term safety data on IGF-1 LR3 itself

Instead of 10-15% of follicles resting at once, 30% or more might enter telogen simultaneously

At various time points, the DiR signals in the brains of mice treated with DiR-Lip@BMn was consistently weaker, indicating reduced brain-targeting efficiency due to the presence of BBB

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