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TME, tumor microenvironment

Investigating dietary patterns, such as adherence to anti-inflammatory or Mediterranean-type diets, as well as the adequacy of specific micronutrient intakes, may provide valuable insights into preventive strategies, symptom modulation, and improved patient outcomes

While MPNST remains a challenging malignancy, several promising advances are underway: MEK Inhibitors in NF1-Associated MPNST Given the dysregulation of the RAS/RAF/MEK pathway in NF1-related tumors, MEK inhibitors like selumetinib have shown efficacy in benign plexiform neurofibromas

Conventional Medicine: Can the Two Approaches Work Together

NRF2 is reported to have suppressive effects on the lipogenic pathway via inhibiting the activity of LXR 64,70 , a transcription factor that supports lipid synthesis