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If abdominal pain is severe, persistent, or accompanied by fever, it could indicate pancreatitis, a rare but serious complication

DOX is a highly toxic molecule and induces drug resistance due to the overexpression of ABCB1 efflux pump and other related proteins 127

doi: 10.1016/j.biochi.2015.06.020 92

Important Considerations While the dual benefit of GLP-1 medications is promising, several considerations deserve attention

The IGF-1/IGF-1R system has been shown to be an important promoter of tumor growth in various cancers, promoting tumor progression and metastasis by regulating multiple signaling pathways, such as those of PI3K/AKT and MAPK/ERK signaling (78,94)