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If you find yourself consistently eating below these thresholds, that is not dedication

Specifically, the patients were asked How fatigued have you been on average during the past week on a scale of 0 10, zero meaning as badly fatigued as you can imagine and 10 meaning not fatigued at all (translated from Finnish)

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While this is not a contraindication, it necessitates a heightened awareness of symptoms

Most people reach that top dose around the fourth month