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The treatment policy (secondary) estimand evaluated the treatment effect for all randomised participants regardless of trial product discontinuation or use of rescue medication
We are more confident of the decreased risk in GLP-1 medications compared to metformin and insulin. Because this was a retrospective, large database study, it relied on accurate ICD coding by clinicians, notes Dr
10.3136/fstr.17.103 50 JangJ
UK approval through the MHRA may come separately and could be faster since Brexit allowed the UK to conduct independent reviews
Regular blood tests to assess nutritional status (including vitamin B12, particularly if also taking metformin, iron, and vitamin D levels) may be appropriate for some patients, particularly those with significantly reduced food intake
